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Detailed considerations based on current knowledge are presented below

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Key limitations of the current research include: Small sample sizes in early or pilot human studies Heavy reliance on animal models that may not reflect real-world substance use Limited duration of studies and inconsistent outcome measures The absence of FDA approval for GLP-1 medications in treating substance use disorders Important context to keep in mind: Addiction is influenced by psychological, social, and environmental factors beyond biology Medications alone are not sufficient to address substance use disorders Evidence-based therapies remain the standard of care At this time, GLP-1 medications should not be considered treatments for opioid, nicotine, or stimulant use disorders

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